Arizona Cardinals vs. Jacksonville Jaguars Betting Preview, Odds and Pick

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Cardinals at Jaguars
Cardinals vs. Jaguars Pick – Arizona Cardinals -7.5 (-105)
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On Sunday, September 26th, the Arizona Cardinals trade in one hot, sunny location for another as they travel to Florida to take on the Jacksonville Jaguars.

The Cardinals are 2-0 and soaring high with an explosive offense and an improved defense. The Jaguars are sitting at 0-2 and appear to be one of the worst teams this season as they continue their rebuild.

Will the Cardinals remain unbeaten or will the Jaguars pick up their first win of the season?

Kickoff inside TIAA Bank Field is at 1pm ET.

Cardinals vs. Jaguars Live Odds and Betting History

The following odds are courtesy of BetOnline:

Teams Spread Moneylines Totals
Arizona Cardinals -7.5 (-110) -355 Over 52 (-110)
Jacksonville Jaguars +7.5 (-110) +285 Under 52 (-110)
Betting Data Arizona Cardinals Jacksonville Jaguars
2021 Record 2-0 0-2
2021 Home 1-0 0-1
2021 Away 1-0 0-1
2021 ATS 1-1 0-2
2021 ATS Home 0-1 0-1
2021 ATS Away 1-0 0-1
2021 O/U 1-1 1-1
2021 O/U Home 1-0 0-1
2021 O/U Away 0-1 1-0

Cardinals vs Jaguars NFL Game Preview

Arizona and Jacksonville have played against each other five times with the Cardinals holding a 3-2 lead in this series. Arizona has also won three in a row with the most recent contest coming in 2017 where the Cardinals won 27 to 24.

Arizona also holds a 2-1 advantage in games played at Jacksonville with the last contest coming in 2013 where the Cardinals won 27 to 14.

The Cardinals (2-0) look unstoppable on offense. Led by Kyler Murray, this unit is scoring 36ppg with a QB that’s already becoming a favorite to win the NFL MVP. If the defense shows up this weekend, then Jacksonville has no hope of winning.

The Jaguars (0-2) are struggling on both sides of the ball and clearly have the look of a rebuilding team. With a rookie QB and head coach, Jacksonville is in for a long season. At least there’s optimism for the future. Unfortunately, the 2021 season is already a lost cause.

Opening Odds and Line Movement for Game

The line opened with Arizona favored by 6.5 points at NFL betting sites. The spread quickly moved to -7.5 points following the Week 2 games. The Over/Under opened at 50.5 points and has slowly climbed up to an O/U of 52 total points.

Head to Head Betting Trends

  • Arizona is 3-2 SU in the last five meetings
  • Arizona is 3-2 ATS in the last five matchups
  • The Over is 4-1 in last five games
  • Arizona is 2-1 SU at Jacksonville

Arizona Cardinals Betting Trends

  • 4-2 SU in last six games
  • 4-2 SU in last six AFC games
  • 2-5 SU in last seven grass games
  • 8-1 SU in last nine AFC South games
  • 3-8 ATS in last 11 games
  • 3-10 ATS in last 13 games as the Favorite
  • 2-6 ATS when a Favorite of 3.5 to 9.5pts
  • 10-6 ATS in last 16 road games
  • 1-4 ATS in last five Week 3 games
  • Under is 7-0 in last seven road games

Jacksonville Jaguars Betting Trends

  • 0-10 SU in last 10 games
  • 0-8 SU in last eight home games
  • 0-11 SU in last 11 NFC games
  • 3-11 SU when an Underdog of 3.5 to 9.5pts
  • 5-23 SU as an Underdog
  • 3-16 SU following 2 or more consecutive losses
  • 1-5 ATS in last six games
  • 2-6 ATS in last eight NFC games
  • Over is 8-0 in last eight NFC games

Free NFL Bet and Game Prediction: Cardinals -7.5 (-105)

There’s really nothing, other than an injury to Kyler Murray, that can make me think that Jacksonville has a chance in this matchup on Sunday.

The Jaguars may play tough in the first half, but I fully expect the Cardinals to pull away by time we get to the 4th quarter, win by a comfortable margin and cover the spread.

Here are a few reasons why I believe that:

Arizona’s Offense Will Go Up and Down the Field

Currently, the Cardinals have one of the most explosive offenses in the league. After two games, they’re averaging 36ppg, 464 total yards per game, 344.5 passing ypg, and 119.5 rushing ypg.

Star receiver Deandre Hopkins isn’t even leading the team in yards or receptions, yet he’s made his presence felt with 10 receptions for 137 yards and 3 TDs. Other receivers like Kirk, Moore and Green are benefitting from Hopkins taking on the opposing defense’s best corner.

Arizona’s running game has a nice balance with Edmonds and Conner. Murray also chips in on the ground.

The Jaguars are allowing 30ppg, 437 total ypg, 309.5 passing ypg, and 128 rushing ypg. This is a recipe for disaster when Arizona takes the field.

The Arizona Pass Rush Will Wreak Havoc

In Week 1 of the regular season, Arizona forced three turnovers and tallied six sacks against a subpar Tennessee offensive line. They took a step back last weekend against a much better Minnesota offensive line.

However, the Jaguars’ offensive line is as bad as Tennessee’s if not worse. I fully expect Watt and Chandler to be in the backfield for most of the game. I also see a few turnovers as Lawrence has already thrown five INTS on the year.

Arizona’s defense gives up 362.5 total ypg and 23ppg, but I don’t see the Jaguars coming close to those numbers. Jacksonville can’t run the ball as they average only 75ypg. And, their passing numbers of 225ypg is inflated due to playing from behind and plenty of garbage time.
The Jaguars average 17ppg and will be lucky to hit that mark this weekend.

Kyle Murray is Unstoppable

The biggest reason why Arizona sports a 2-0 record and is soaring on offense is due to Kyler Murray. After two weeks, he has 689 passing yards and 7TDs along with 51 rushing yards and 2 TDs.

He’s already come out in 2021 playing at a high level and motivated to get this team to the Playoffs. If the offense sees their running game improve then this team is going to be a force to be reckoned with.

Last weekend, Jacksonville allowed Teddy Bridgewater to throw for 328 yards and 2 TDs. In week 1, they allowed Tyrod Taylor to throw for 291 yards and 2 TDs. I expect Murray to put up another 300-yard passing game with at least 3 total TDs.

Take the Cardinals to cover this spread regardless of what the past betting trends have to say. The talent level between these two teams is too much for Jacksonville to overcome. I like the Cardinals to win by two touchdowns at 30 to 17.

Pick: Cardinals -7.5
Odds: -105
$100 Could Win You...$195.24

Cardinals vs. Jaguars Betting Recap:

  • Oddsmaker: BetOnline
  • Moneylines: Cardinals (-355) vs Jagars (+285)
  • Spread: Cardinals -7.5 (-105)
  • Over/Under: 52 total points (-110)
  • Prediction: Cardinals 30 – Jaguars 17
Rick Rockwell

As a longtime freelance writer, avid sports fan, former athlete, and experienced sports bettor, Rick Rockwell has risen up the ranks at to become the self-professed "King of the Blog" in his first year with the site. ...

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