NFC West SNF Battle: Rams vs 49ers Betting Preview, Odds and Pick

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LA Rams vs San Fran NFL
Pick: Rams -3.5
Odds: -110
$100 Could Win You...$190.91

Week 6’s Sunday Night Football game is a matchup between the surging Los Angeles Rams and the struggling San Francisco 49ers. The outcome of this game could have a big impact on the NFC West standings as both teams are chasing after the undefeated Seattle Seahawks.

Can the 49ers rebound from two straight losses or will the Rams make San Francisco a permanent resident in the basement of the division? Kickoff inside Levi’s Stadium is at 8:20PM ET.

Rams vs 49ers Live Odds and Betting History

The following odds are courtesy of BetOnline:

Teams Spread Money Lines Totals
Los Angeles Rams -3.5 (-110) -180 Over 51.5 (-110)
San Francisco 49ers +3.5 (-110) +160 Under 51.5 (-110)
Betting Data Los Angeles Rams San Francisco 49ers
2020 Record 4-1 2-3
2020 Home 2-0 0-3
2020 Away 2-1 3-0
2020 ATS 3-2 2-3
2020 ATS Home 1-1 0-3
2020 ATS Away 2-1 2-0
2020 O/U 2-3 3-2
2020 O/U Home 0-2 1-2
2020 O/U Away 2-1 2-0

Rams vs 49ers NFL Game Preview

These two divisional rivals have played against each other 141 times. The 49ers lead the all-time series with a record of 71-67-3. The 49ers swept both games last year and are 35-34-2 at home against the Rams.

  • The LA Rams (4-1) crushed Washington in Week 5 and remain one game back of Seattle in the NFC West. Their offense rebounded from a poor performance in Week 4 vs the Giants, but it was the defense that led the charge last week. Can the Rams hand a crushing defeat to their California rivals?
  • The San Francisco 49ers (2-3) are coming off an embarrassing loss to the Dolphins in Week 5. San Francisco looked inept on offense and pathetic on defense. Furthermore, the team has lost two straight games and is winless at home this season. Can the 49ers get a big divisional win and improve to .500?

Head to Head Betting Trends

  • 49ers are 6-4 SU in last 10 games
  • 49ers are 6-4 ATS in last 10 meetings
  • The O/U is 5-5 in last 10 contests
  • Under is 5-2 in last seven games at San Francisco

Los Angeles Rams Betting Trends

  • 5-1 SU in last six overall games
  • 5-0 SU in their last five NFC games
  • 14-2 SU when a favorite of 3.5 to 9.5pts
  • 13-7 SU in last 20 road games
  • 9-3 SU in last 12 NFC West games
  • 12-3 SU when playing a losing team
  • 10-5 ATS against losing teams
  • 9-3 ATS in last 12 NFC West games
  • 13-7 ATS in last 20 road games
  • Over is 4-1 in last five road games

San Francisco 49ers Betting Trends

  • 2-4 SU in last six overall games
  • 13-4 SU in last 17 NFC gams
  • 5-2 SU in last seven NFC West games
  • 1-7 SU when an underdog of 3.5 to 9.5pts
  • 2-5 SU after losing two games in a row
  • 2-4 ATS in last six overall games
  • 2-5 ATS in last seven home games
  • 1-4 ATS in last five October games
  • Over is 6-1 in last seven Week 6 games

Depending on which NFL betting site you looked at, the 49ers opened as a -2.5 to -3 point favorite. Since then, the Rams have become the favorite by 3.5 points. The Over/Under opened at 49 points and has gone up to 51.5 total points.

Free NFC West Sports Bet and Game Prediction: Rams -3.5 (-110)

If you watched the 49ers game against the Dolphins last weekend then you would’ve seen arguably the worst performance by this team in a few years. It was an embarrassing 47 to 17 loss and one that certainly showed just how bad the 49ers are right now.

San Francisco has dropped two straight games, is winless at home, and only has victories over the two worst teams in the NFL: the Giants and the Jets.

Furthermore, San Francisco’s QB Jimmy G. was benched last weekend due to poor play. He looked like he had never stepped foot on a football field before. It was a horrible performance from a quality starting QB.

In their three losses, the 49ers are averaging just 19ppg. That’s not going to cut it versus the Rams this weekend as Los Angeles looks like they could be a Playoff contender once again.

The Rams’ lone loss on the year came against Buffalo on a last second TD pass. Otherwise, this team is playing great football on both sides of the ball.

LA’s offense has returned to their high output ways as they average 27.2 ppg including 139.6 ypg on the ground. QB Jared Goff and the passing attack is averaging 274.4 ypg.

The Rams defense is allowing just 18ppg, which is about what the 49ers are averaging in their losses. Led by Aaron Donald, LA’s defense has returned to their level of play from two seasons ago. They’re allowing just 224 passing ypg which doesn’t bode well for the 49ers this weekend.

Whether it’s Jimmy G., Beathard or Mullens, this 49ers offense is going to struggle against the Rams on Sunday night. It may be close in the first half, but I expect the Rams to pull away in the second half and win by at least a TD.

In the Rams four wins this season, they’re average margin of victory is 12.25 points. I see them coming close to that mark this weekend against San Francisco.

The Rams are 10-5 ATS in their last 15 games against teams with losing records and 9-3 ATS in their last 12 divisional games. The 49ers are 2-4 ATS in their last six overall games and 2-5 ATS in their last seven home games including 0-3 this season.

Look for the Rams offense to roll all game long and for their defense to control the line of scrimmage. They will make life difficult for the 49ers offense before San Francisco scores some garbage time points.

Rams vs 49ers Betting Recap:

  • Oddsmaker: BetOnline
  • Moneylines: Rams (-180) vs 49ers (+160)
  • Spread: Rams -3.5 (-110)
  • Over/Under: 5 total points (-110)
  • Prediction: Rams 30 – 49ers 20
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Rams vs 49ers Pick

Rams -3.5 (-110)

Rick Rockwell

As a longtime freelance writer, avid sports fan, former athlete, and experienced sports bettor, Rick Rockwell has risen up the ranks at to become the self-professed "King of the Blog" in his first year with the site. ...

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