Carolina Panthers vs San Francisco 49ers Betting Preview, Odds and Pick

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On Sunday, October 27th, the Carolina Panthers head across country to take on the undefeated San Francisco 49ers in an NFC showdown. San Francisco continues to impress with one of the league’s best defenses while the Panther feature MVP candidate Christian McCaffrey.

Carolina has gone 4-0 since Kyle Allen took over the starting QB spot from an injured Cam Newton. Will the Panthers continue their winning streak with Allen or will the 49ers flex their muscles and shut down an explosive Carolina offense? Kickoff inside Levi’s Stadium is at 4:05 PM ET.

Panthers vs 49ers Live Odds and Betting History

The following odds are courtesy of our live odds feed:

Betting Data Carolina Panthers San Francisco 49ers
2019 Record 4-2 6-0
2019 Home 1-2 2-0
2019 Away 3-0 4-0
2019 ATS 4-2 4-2
2019 ATS Home 1-2 1-1
2019 ATS Away 3-0 3-1
2019 O/U 4-2 1-5
2019 O/U Home 2-1 0-2
2019 O/U Away 2-1 1-3

Carolina vs San Francisco Week 8 Game Preview

These two teams have played against each other a total of 21 times with the Panthers leading the series 13-8. The last time they faced off was the beginning of 2017 when the Panthers won at San Francisco by a score of 23 to 3.

Carolina is 5-1 in the last six head to head meetings and 4-1 in the last five games played at San Francisco. The one win that the 49ers had over the last 15 years is an NFC playoff game in 2014.

Carolina (4-2) is coming off a bye week after dismantling Tampa Bay in London two weeks ago. They’ve won four straight games and have seen a resurgence on defense as well. What started off as a rough 0-2 record, the Panthers are now clawing their way to respectability and a potential Wild Card spot down the line.

The 49ers (6-0) continue to win no matter how ugly it looks. Last weekend, they defeated Washington 9-0 and pitched an impressive shutout in bad weather. Over the last three games, San Francisco has outscored their opponents 60 to 10. Will that trend continue this weekend against the Panthers?

The 49ers opened as the favorite with a spread of -5.5 to -6.5 points depending on the NFL betting site. It has reached as high as -7 points before settling at -5.5 points with most online betting sites.

The Over/Under opened at 41.5 points and has settled at 42 total points with most sports betting sites. The 49ers’ moneyline started at -244 and has floated around the -250 mark. The Panthers opened at +194, but have gone up as high as +210 with many football betting sites.

Free NFL Sports Bet and Game Prediction: Carolina Panthers +5.5 (-105)

This game is going to come down to which defense can make the most plays. With that said, the 49ers appear to have the advantage in that matchup.

San Francisco only allows 10.7 ppg and has given up only 10 points in the last three games combined. Furthermore, they’ve allowed just 249 total ypg, 150 passing ypg, and 90 rushing ypg. With that said, they’re facing the best all-around running back in the NFL right now – Christian McCaffrey.

Not only is McCaffrey lighting up the league, he’s also being hailed as an MVP candidate. In six games, he’s already amassed 618 rushing yards, 35 receptions for 305 yards, and nine total TDs. He’s scored in every game so far, but one.

Since Kyle Allen has taken over as starting QB, McCaffrey is averaging 165.5 total yards per game and 2.25 TDs per game. He’s the best player on the Panthers and the biggest threat to the 49ers defense on Sunday.

Offensively, the 49ers have the best rushing attack in the league as they average 172.7 ypg. However, the Panthers have seen their rush defense improve as they allow 119 rushing ypg. Over the last three weeks, they’ve allowed just 95 rushing ypg. I believe this will be the difference in the game.

If the Panthers can slow down the 49ers rushing attack then I see Carolina having a good shot at winning this game. However, if the 49ers can succeed at running the ball then that will open up their play action passing attack which will make them a more complete and dangerous offense.

Despite playing two less games than Jimmy G., Panthers QB Kyle Allen has only 400 less passing yards and the same amount of TDs at seven apiece. However, Allen hasn’t thrown an interception yet and Jimmy G. has already thrown six. I’m not 100% sold on Jimy Garoppolo especially against a tough defense.

Carolina is 4-1 ATS in their last five games, 7-1 ATS in their last eight games against San Francisco, 9-1 ATS in their last 10 games at San Francisco, 8-4 ATS following a divisional game, 2-0 SU after a Bye Week, 8-4 ATS in Weeks 5 through 9, and 10-4 ATS when playing against teams with winning records.

The 49ers are 3-7 ATS in their last 10 games as the betting favorite, 2-3 ATS when a favorite of 3.5 to 9.5 points, and 1-6 ATS in their last seven games against the NFC South.

If Carolina can stop the run then I believe they will win the game. However, that’s easier said than done. Allen has played better than Garoppolo and I believe he will continue that trend this Sunday. McCaffrey needs a big game against the 49ers for Carolina to have their best chance at winning.

Just like my lack of confidence in Jimmy G., I’m not 100% confident that Carolina can go in and upset the 49ers despite their recent success at San Francisco. However, I do feel good about the Panthers covering a 5.5 point spread. In fact, if you can shop around and find this spread at 6 points or more then I would jump all over it.

I wouldn’t be surprised if Carolina pulled off the upset as they certainly have the ability to. However, I’m not ready to pick them to win outright. I am ready to pick them to cover the 5.5 points and keep this a close ball game.

Panthers vs 49ers Betting Recap:

  • Oddsmaker: BetOnline
  • Moneylines: Panthers (+210) and 49ers(-250)
  • Spread: 49ers -5.5 (-115)
  • Over/Under: 42 total points (-110)
  • Prediction: 49ers 23 – Panthers 20
Rick Rockwell

As a longtime freelance writer, avid sports fan, former athlete, and experienced sports bettor, Rick Rockwell has risen up the ranks at to become the self-professed "King of the Blog" in his first year with the site. ...

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